Velazquez Lab of Neurodegenerative Diseases - VLoND

Publications

  1. Bartholomew SK, Winslow W, Sharma R, Pathak KV, Tallino S, Judd J, Leon H, Pirrotte P, Velazquez R, 2024. "Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease-like pathology despite a 6-month recovery period in mice." J. Neuroinflammation, In press, officially accepted November 7th, 2024. DOI: 10.1186/s12974-024-03290-6
  2. Tallino S, Etebari R, McDonough I, Leon H, Sepulveda I, Winslow W, Bartholomew SK, Perez S, Mufson E, Velazquez R, 2024. "Dietary choline supplementation in adult Down syndrome mice enhances health outcomes". BioRxiv, under review in Nutrients, November 5th, 2024. https://www.biorxiv.org/content/10.1101/2024.09.26.615088v1
  3. Judd JM, Jasbi P, Winslow W, Serrano GE, Klein-Seetharaman J, Beach T, Velazquez R, 2023. "Inflammation and the pathological progression of Alzheimer's disease are associated with low circulating choline levels. Acta Neuropathologica, PMID: 37548694
  4. Ávila C, Suazo C, Nolz J, Cochran JN, Wang Q, Velazquez R, Dammer E, Readhead B, Mastroeni D, 2023. Reduced PIN1 gene expression in neocortical and limbic brain regions in female Alzheimer’s patients correlates with cognitive and neuropathological phenotypes. BioRxiv, Doi: https://doi.org/10.1101/2023.08.14.553279
  5. Tallino S, Winslow W, Velazquez R, 2023. "Pathological trajectory in the Ts65Dn model of Down syndrome." Aging, PMID: 36707069
  6. Dave N, Judd JM, Decker A, Winslow W, Sarette P, Villarreal Espinosa O, Tallino S, Bartholomew SK, Bilal A, Sandler J, McDonough I, Winstone JK, Blackwood EA, Glembotski C, Karr T, Velazquez R, 2023. "Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks." Aging Cell, 00, e13775. PMID: 36642814
  7. Dave N, Judd JM, Decker A, Winslow W, Sarette P, Espinosa OV, Sandler J, Bilal A, Tallino S, McDonough I, Winstone JK, Blackwood EA, Glembotski C, Karr T, Velazquez R. "Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks." Biorxiv, Doi: https://doi.org/10.1101/2022.08.14.503929
  8. Winstone JK, Pathak K, Winslow W, Piras IS, White J, Sharma R, Huentelman MJ, Pirrotte P, Velazquez. "Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders." J. Neuroinflammation, PMID: 35897073
  9. Tallino S, Winslow W, Bartholomew SK, Velazquez R, 2022. "Temporal and brain region-specific elevations of soluble Amyloid-β 40-42 in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease." Aging Cell, PMID: 35290711
  10. Powers B, Velazquez R, Strawderman MS, Ginsberg SD, Muson EJ, Strupp BJ, 2021. "Maternal choline supplementation as a potential therapy for Down syndrome: Assessment of effects throughout the lifespan." Front. Aging Neurosci, PMID: 34690739
  11. Winslow W, McDonough I, Tallino S, Decker A, Vural AS, Velazquez R, 2021. "IntelliCage automated behavioral phenotyping reveals behavior deficits in the 3xTg-AD mouse model of Alzheimer's disease associated with brain weight." Front. Aging Neurosci, PMID: 34483889
  12. Dave N, Vural AS, Piras IS, Winslow W, Surendra L, Winstone J, Beach T, Huentelman MJ, Velazquez R, 2021. "Identification of the retinoblastoma binding protein 7 (Rbbp7) as a mediator against tau acetylation and subsequent neuronal loss in Alzheimer’s disease and related tauopathies." Acta Neuropathologica, PMID: 33978814
  13. Mifflin MA, Winslow W, Surendra L, Tallino S, Vural A, Velazquez R, 2021. "Sex differences in the IntelliCage and Morris water maze in the APP/PS1 mouse model of amyloidosis." Neurobiol. of Aging, PMID: 33610962
  14. Velazquez R, Winslow W, Mifflin MA, 2020. "Choline as a prevention for Alzheimer’s Disease." Aging, PMID: 32039834
  15. Velazquez R, Ferreira E, Knowles S, Fux C, Rodin A, Winslow W, Oddo S, 2019. "Life-long choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation." Aging Cell, PMID: 31560162
  16. Velazquez R, Meechoovet B, Ow A, Foley C, Shaw A, Smith B, Oddo S, Hulme C, Dunckley T, 2019. "Chronic Dyrk1 Inhibition Delays the Onset of AD-like Pathology in 3xTg-AD Mice." Mol Neurobiol, PMID: 31240602
  17. Velazquez R, Ferreira E, Winslow W, Dave N, Piras I, Naymik M, Huentelman M, Tran A, Caccamo A, Oddo S, 2019. "Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations." Mol. Psychiatry, PMID: 30622336
  18. Belfiore R, Rodin A, Ferreira E, Velazquez R, Branca C, Caccamo A, Oddo S, 2018. "Temporal and Regional Progression of Alzheimer’s disease-like pathology in 3xTg-AD mice." Aging Cell, PMID: 30488653
  19. Velazquez R, Tran A, Ferreira E, Turner EC, Oddo S, 2018. "Acute Tau knockdown in the hippocampus of adult mice causes learning and memory deficits." Aging Cell, 17, 1-12. PMID: 29749079
  20. Velazquez R, Tran A, Ishimwe E, Denner L, Dave N, Oddo S, Dineley KT, 2017. "Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer’s disease." Neurobiol. of Aging 58, 1-13. PMID: 28688899
  21. Powers BP, Kelly CM, Velazquez R, Ash JA, Strawderman MS, Alldred MJ, Ginsberg SD, Mufson EJ, Strupp BJ, 2016. "Maternal choline supplementation in a mouse model of Down syndrome: effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring." Neuroscience 340, 501-514. PMID: 27840230
  22. Velazquez R, Shaw DM, Caccamo A, Oddo S, 2016. "Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease." Mol Neurodegener. 11, 1 – 14. PMID: 27412291
  23. Powers BP*, Velazquez R*, Kelley CM, Ash JA, Strawderman MS, Alldred MJ, Ginsberg SD, Mufson EJ, Strupp BJ, 2016. "Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome." Brain Struct Funct. 221, 4337-4352. PMID: 26719290
  24. Kelley CM, Ash JA, Powers BP, Velazquez R, Alldred MJ, Ikonomovic MD, Ginsberg SD, Strupp BJ, Mufson EJ, 2016. "Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome." Curr Alzheimer’s Res. 1, 84-96. PMID: 26391045
  25. Strupp BJ, Powers BE, Velazquez R, Ash JA, Kelley CM, Alldred MJ, Strawderman MS, Caudill MA, Mufson EJ, Ginsberg SD, 2016. "Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease." Curr Alzheimer’s Res. 13, 97-106. PMID: 26391046
  26. Talboom JS, Velazquez R, Oddo S, 2015. "The mammalian target of rapamycin at the crossroad of aging and Alzheimer’s disease." Aging and mechanism of disease. PMID: 28721257
  27. Ash JA*, Velazquez R*, Kelley CM, Powers BE, Ginsberg SD, Mufson EJ, Strupp BJ, 2014. "Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice." Neurobiol. Dis 70, 32-42. PMID: 24932939
  28. Kelley CM, Powers BP, Velazquez R, Ash JA, Ginsberg SD, Strupp BJ, Mufson EJ, 2014. "Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice." J Com Neurol. 522, 1390-1410. PMID: 24178831
  29. Kelley CM, Powers BP, Velazquez R, Ash JA, Ginsberg SD, Strupp BJ, Mufson EJ, 2013. "Sex differences in the cholinergic basal forebrain in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease." Brain Pathol. 24, 33-44. PMID: 23802663
  30. Velazquez R, Ash JA, Powers BE, Kelley CM, Strawderman MS, Luscher ZI, Ginsberg SD, Mufson EJ, Strupp BJ, 2013. "Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome." Neurobiol. Dis 58, 92-101. PMID: 23643842